Concentration–response curves for endothelin-1 (ET-1)–induced contraction in human bronchi after 15 hours of incubation with 0.1 µM fenoterol or Krebs–Henseleit solution for the paired control in presence or in absence of: (A) Wortmaninn (1 µM); (B) Y27632 (1 µM); (C) Pioglitazone (1 µM); (D) FH535 (0.3 µM).

Open circles, control; Filled circles, 0.1 µM fenoterol; Open square, control + pretreatment; Filled square, fenoterol + pretreatment. Values are means ± SEM. For comparisons, see Tables 1 and 2.