Concentration–response curves for endothelin-1 (ET-1)–induced contraction in human bronchi after 15 hours of incubation with 0.1 µM fenoterol or Krebs–Henseleit solution for the paired control in presence or in absence of: (<i>A</i>) Wortmaninn (1 µM); (<i>B</i>) Y27632 (1 µM); (<i>C</i>) Pioglitazone (1 µM); (<i>D</i>) FH535 (0.3 µM).

<p>Open circles, control; Filled circles, 0.1 µM fenoterol; Open square, control + pretreatment; Filled square, fenoterol + pretreatment. Values are means ± SEM. For comparisons, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111350#pone-0111350-t001" target="_blank">Tables 1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111350#pone-0111350-t002" target="_blank">2</a>.</p>