Comparison of measured γH2AX dose response curves to model predictions including the 3D spreading mechanism for H2AX phosphorylation.

Normalized γH2AX dose response curve for AGD (full squares) and CHO (open squares) cells, and corresponding model predictions of phosphorylated domains assuming random extension of H2AX phosphorylation around the hit domain; a DSB induction rate of 30 and 60 DSB/Gy was considered.