Co-expression of CXCR4 and mMCP-6 by MCs in mouse RCAS-<i>KRas</i>+RCAS-<i>Akt</i> induced gliomas.

<p>(<b>A</b>) Immunofluorescence staining for CXCR4 and mMCP-6 was performed in both <i>Ntv-a Arf−/−</i> and <i>Gtv-a Arf−/−</i> mouse gliomas, demonstrating co-expression of CXCR4 and mMCP-6. Scale bar = 50 µM. (<b>B</b>) Immunofluorescence staining, demonstrated co-localization of CXCR4 and mMCP-6 at the single-cell level in both <i>Ntv-a Arf−/−</i> and <i>Gtv-a Arf−/−</i> mouse gliomas. Maximum intensity projection of z-stack confocal images was applied. Scale bar = 20 µM. (<b>C</b>) The quantification of MCs in mouse brain tumors revealed about 90% to be CXCR4-positive in the corresponding objective fields with no difference between <i>Ntv-a Arf−/−</i> (n = 5) and <i>Gtv-a Arf−/−</i> (n = 5). Error bars show SD.</p>



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