Fig_4.tif (1.35 MB)
Clustal Omega alignment of soluble single-chain antibody Fv domain-alkaline phosphatase (scFv-AP) antibody sequences.
figure
posted on 2015-12-23, 10:06 authored by Christopher G. Hosking, Hamish E. G. McWilliam, Patrick Driguez, David Piedrafita, Yuesheng Li, Donald P. McManus, Leodevico L. Ilag, Els N. T. Meeusen, Michael J. de VeerComplementarity determining regions (CDR) regions of variable light (CDRL1-3) and variable heavy (CDRH1-3) chains are indicated in boxes. Respective VL and VH regions show similarity within the framework regions and distinct differences within CDR regions, particularly within CDRH3. (*) indicates a fully conserved residue, (:) a strongly similar and (.) a weakly similar residue.
