Clomipramine did not rescue deficient SC-CA1 long-term potentiation in subordinate tree shrews.

(A) Micrograph showing the positions of the stimulating electrode (S) and the recording electrode (R) in the tree shrew hippocampal CA1 (scale bar: 350 µm). (B) LTP induced by high-frequency stimulation (HFS) in Naïve (N = 4 animals, n = 6 slices), Sub+Sal (N = 4, n = 5), and Sub+Clo tree shrews (N = 4, n = 7). Inset above: Typical fEPSPs recorded at baseline and 50−60 min post-HFS (horizontal bar: 5 ms, vertical bar: 0.5 mV for each group). (C) There was no significant difference in LTP at 50−60 min post-HFS between the Sub+Sal and Sub+Clo group. Both groups exhibited impaired LTP compared to the Naïve group. *p<0.05 compared to the Naïve group.