Clinicopathological significances of pre-operative plasma OPN level.

<p>(<i>A</i>) Correlation of pre-operative plasma OPN level with the paired tumor OPN transcript level in 32 CRC patients (R = 0.452, p = 0.010; Pearson correlation). (<i>B</i>) Correlation of pre-operative plasma OPN level with tumor size (R = 0.390, p<0.001; Pearson correlation). (<i>C</i>) Comparison of pre-operative plasma OPN levels in patients with tumor ≥5 or <5 (p = 0.003; Student’s t-test) (left). (<i>D</i>) Comparison of pre-operative plasma OPN levels in patients with lower (I to II) or higher stage (III to IV) (p<0.001; Student’s t-test). (<i>E</i>) Comparison of pre-operative plasma OPN levels in patients with or without distant metastasis (p = 0.003; Student’s t-test). (<i>F</i>) Comparison of pre-operative plasma OPN levels in patients with or without post-operative metastasis (p = 0.951; Student’s t-test). All data are representative of three independent experiments.</p>