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Characterization of Mct1 expression patterns in cells transfected with full length and deletion mCherry-Mct1 expression constructs.
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posted on 2014-01-16, 02:48 authored by Amy L. Uhernik, Lun Li, Nathan LaVoy, Micah J. Velasquez, Jeffrey P. SmithA. Protein motifs in the C and N termini of Mct1 that could be involved in controlling its localization to vesicles include (in red); type 1 and 4 WW ligands, an AP2 clathrin interaction site, a PDZ ligand, a hydrophobic N terminus, a charged C terminus (+ and −), lysine residues (shown in green), and numerous phosphorylation sites (PO4−). B. Confocal micrographs showed a similar appearance of Mct1 vesicles among cells expressing FL, XC, and XN mCherry-Mct1. C. An epi-fluorescence micrograph of an RBE4 cell expressing the C-terminus of Mct1 with mCherry fused to its amino terminus.
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BiochemistryproteinsTransmembrane transport proteinsMolecular cell biologyCellular structuresSubcellular organellesSignal transductionSignaling cascadescAMP signaling cascadeneuroscienceMolecular neuroscienceSignaling pathwaysNeurobiology of disease and regenerationmct1patternscellstransfecteddeletionmcherry-mct1
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