Changes in poisoning deaths involving co-proxamol, other analgesics, and all drugs, in England and Wales, 1998–2010, associated with the Committee on Safety of Medicines (CSM) announcement in January 2005.

a<p>Using interrupted time-series segmented regression analysis where the intervention point is taken as the end of 2004 (the CSM announcement on the withdrawal of co-proxamol, January 2005).</p>b<p>Estimated for the midpoint quarter of 2005–2010. See <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001213#pmed.1001213.s002" target="_blank">Text S1</a> for method, equation (2) or (3).</p>c<p>Absolute difference of estimated number with CSM announcement and estimated number without CSM announcement, taken at the mid-point of the post-intervention period, see <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001213#pmed.1001213.s002" target="_blank">Text S1</a> equation (4).</p>d<p>95% CIs taken from Stata results or calculated according to Zhang et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001213#pmed.1001213-Zhang1" target="_blank">[38]</a>.</p>e<p>Other analgesics include: co-codamol, codeine, co-dydramol, dihydrocodeine, NSAIDS, paracetamol, and tramadol.</p>