Casticin induced DR5 and CHOP upregulation and enhanced TRAIL-induced apoptosis of BGC-823 cells in a ROS-dependent manner.

<p>Effects of casticin on ROS generation (A and B) and the effects of NAC on casticin-induced DR5 and CHOP upregulation (C) using western blot analysis and TRAIL-mediated apoptosis (D) in BGC-823 cells (mean±SD, <i>n</i> = 3). <sup>*</sup><i>P<0.05</i> vs. treatment with DMSO; <sup>#</sup><i>P<0.05</i> vs. treatment with 1 µmol/l casticin plus 50 ng/ml TRAIL in cells pretreated with NAC.</p>