Figure_6.tif (1.34 MB)

Canonical pathways involving deregulated genes.

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posted on 2014-05-30, 03:48 authored by Ingrid Medina-Martinez, Valeria Barrón, Edgar Roman-Bassaure, Eligia Juárez-Torres, Mariano Guardado-Estrada, Ana María Espinosa, Miriam Bermudez, Fernando Fernández, Carlos Venegas-Vega, Lorena Orozco, Edgar Zenteno, Susana Kofman, Jaime Berumen

Panel A shows the top 25 canonical pathways identified in the set of 2,006 deregulated genes in the whole set of tumors. Panel B shows the top 25 canonical pathways identified in the set of 862 genes deregulated exclusively in high-CN tumors. The canonical pathways were identified with the Ingenuity Pathway Analysis software. The -log (p value) and ratio were calculated by comparing the number of genes belonging to the pathway present in the data sets with the human genome database. The p value was calculated using the chi-square or Fisher’s exact test, as appropriate, and values of -log (p value) higher than 1.3 (red line) correspond to a value of p<0.05. The canonical pathway of hypoxia inducible factor (HIF1α) signaling was statistically significant in the deregulated genes in the whole set (43rd place) and in the high-CN set of tumors (26th place).