Fig_5.tif (1.16 MB)
CD39 is highly up-regulated by exhausted CD8+ T cells in a mouse model of chronic infection.
figure
posted on 2015-10-20, 04:53 authored by Prakash K. Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E. Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining(A, B) Expression of CD39 and PD-1 by CD44– naive mouse CD8+ T cells (A) and in CD8+ T cells at indicated times following LCMV Armstrong (acute) or Clone 13 (chronic) infection (B). Representative plots show total (black) and H-2Db GP276-286 tetramer-specific CD8+ T cells (red). Summary of results in 5 mice per group is shown in bar-graphs on the right. Statistical significance was assessed with Mann-Whitney test. *P < 0.5, **P < 0.01.
