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CD39 expressed by CD8+ T cells in HCV infection is enzymatically active.
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posted on 2015-10-20, 04:53 authored by Prakash K. Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E. Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining(A) Flow cytometry sorting gates of CD39+ and CD39– CD8+ T cells and CD39+ CD25+ CD4+ Tregs used for rpHPLC analysis of CD39 activity. (B) Summary of CD39 expression level relative to Tregs in the same subjects. (C) ATP hydrolysis by CD8+ T cell populations relative to Tregs. Data represent 6 patients with chronic HCV infection. Error bars represent SEM. Statistical significance was assessed by paired Student’s t-test (B, C). *P <0.05, **P <0.01.
