CD133-LV transduces CD133+ cells in primary GBM xenografts in the mouse brain.
2014-12-26T03:21:50Z (GMT) by
<p><b>A</b>. Intracranial xenograft tumors were generated using injection of GBML20 cells (5×10<sup>5</sup> cells/animal) and tumor formation (red circle) was confirmed with small animal MRI 1.5 months after injection. High titer stocks of CD133-LV or VSVG-LV expressing TagBFP were injected into the tumor and animals were sacrificed 7 days later for immunofluorescence analysis. <b>B</b>. CD133-LV - transduced cells expressing TagBFP (red) show cell surface immunoreactivity for CD133 (green). <b>C</b>. CD133+ cells were significantly more enriched among TagBFP+ transduced cells in the case of CD133-LV compared to VSVG-LV.</p>