Blocking EPCR decreases tumor growth of human breast cancer cells.

A MDA-MB-231 mfp cells (1×10⁶ cells/mouse) were mixed with 1 mg control IgG or αEPCR-1535 and injected into the mammary fat pad of SCID mice. Blocking EPCR significantly reduced tumor growth and final tumor weights (**p<0.05, T-test, mean±SD, n = 8 mice/group). B MDA-MB-231 mfp cells (1×10⁶ cells/mouse) were injected in the mammary fat pad of SCID mice and mice were treated at days 4, 7 10, 12, and 15 by intraperitoneal injections of 1 mg of control IgG, αEPCR-1500, or αEPCR-1535. Treatment with inhibitory αEPCR-1535 significantly reduced tumor growth and final tumor weights (ANOVA followed by Bonferroni posttest, * p<0.05, ** p<0.005, *** p<0.001 IgG versus αEPCR-1535; # p<0.05 αEPCR-1500 versus αEPCR-1535, § p<0.05 IgG versus αEPCR-1500).