Binding mode of TYY with EphA4 receptor.

(A) 2D interactions between the TYY cyclic peptide and the EphA4 receptor (by LigPlot). Residues with purple bonds in blue labels are from the ligand TYY peptide; residues with brown bonds in red labels are from EphA4. The green dashed line represents a potential hydrogen bond and its length. (B) 3D interactions between the TYY cyclic peptide and the EphA4 receptor (by Pymol). This model was generated by Autodock4, based on the crystal structure of EphA4 in complex with ephrinA2 (PDB: 2WO3). The TYY cyclic peptide is shown as a stick model with grey representing carbon atoms, red representing oxygen atoms and blue representing nitrogen atoms. The EphA4 is shown as a cyan ribbon with key residues shown as yellow sticks. Black dashed lines represent the hydrogen bonds.