Behavioural and physiological phenotypes elicited by Sirt2 knock-down and knock-out in R6/2 mice.

(A–B) Mean body weight measurements in (A) female and (B) male mice. (C–D) Grip strength in (C) female and (D) male mice. (E) Rotarod performance. (F) Brain weight measured at 9 and 15 weeks of age. Error bars represent SEM. WT – wild type, HET – Sirt2HET, KO – Sirt2KO, R6/2 HET – Sirt2HETxR6/2, R6/2 KO – Sirt2KOxR6/2.