Behavioural and physiological phenotypes elicited by <i>Sirt2</i> knock-down and knock-out in R6/2 mice.

<p>(<b>A–B</b>) Mean body weight measurements in (A) female and (B) male mice. (<b>C–D</b>) Grip strength in (C) female and (D) male mice. (<b>E</b>) Rotarod performance. (<b>F</b>) Brain weight measured at 9 and 15 weeks of age. Error bars represent SEM. WT – wild type, HET – <i>Sirt2</i>HET, KO – <i>Sirt2</i>KO, R6/2 HET – <i>Sirt2</i>HETxR6/2, R6/2 KO – <i>Sirt2</i>KOxR6/2.</p>