Bath application of dopamine induces long-lasting facilitation of SW events.
A. Representative traces of CA1 LFPs recorded 5(left) and 15 min after (right) 1-min application of 1 µM dopamine. B. Time course of the percentage of the frequency of SW events relative to the mean value during a 6-min period prior to the dopamine application. Slices were bath-perfused with 1 µM dopamine for 1 min at time 0–1 min. Control slices were perfused continuously with normal extracellular solution. C–E. The mean ratios of the SW event frequency (C), the SW amplitude (D), and the ripple power (150–250 Hz) (E) were calculated from the −5-to-0 min period and the 30-to-35 min period. **P = 0.0082, t8 = 3.49; *P = 0.045, t8 = 2.37, paired t-test versus the −5-to-0 min period. Data are the means ± SEMs of 9 and 5 slices from 7 and 3 mice.
