Bacterial replication in lungs and spleen of C57BL/6 mice vaccinate d with MGM1991, HMA or BCG and challenged with 104 CFU of virulent luminescent M. tuberculosis.

Mean number of bacteria in lungs and spleen of mice vaccinated with 5x104 MGM1991, HMA or BCG or unvaccinated mice (naïve), challenged 12 weeks later with 104 CFU of virulent M.tb by the intratracheal route and sacrificed 4 and 12 weeks after challenge. Results are reported as mean log10 relative light units (RLU) ± SD of 5 mice tested individually; * p < 0.05; ** p < 0.01 (Mann-Whitney test) .