Bacterial replication in lungs and spleen of C57BL/6 mice vaccinate d with MGM1991, HMA or BCG and challenged with 10<sup>4</sup> CFU of virulent luminescent <i>M. tuberculosis</i>.

<p>Mean number of bacteria in lungs and spleen of mice vaccinated with 5x10<sup>4</sup> MGM1991, HMA or BCG or unvaccinated mice (naïve), challenged 12 weeks later with 10<sup>4</sup> CFU of virulent <i>M.tb</i> by the intratracheal route and sacrificed 4 and 12 weeks after challenge. Results are reported as mean log<sub>10</sub> relative light units (RLU) ± SD of 5 mice tested individually; * p < 0.05; ** p < 0.01 (Mann-Whitney test) .</p>