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Attenuation of apoptotic markers levels by Sch B (25 and 50 mg/kg) treatment after Aβ/vehicle infusion.

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posted on 2015-11-10, 03:32 authored by Vijayasree V. Giridharan, Rajarajan A. Thandavarayan, Somasundaram Arumugam, Makoto Mizuno, Hiroyuki Nawa, Kenji Suzuki, Kam M. Ko, Prasanna Krishnamurthy, Kenichi Watanabe, Tetsuya Konishi

(a) Control (b) Aβ-infused (c) Aβ+SchB25 (d) Aβ+SchB50. Representative photomicrographs shows the immunofluorescence detection of (A) Caspase (B) TUNEL -positive cells. From each rat 5–6 coronal brain section were selected and about 15 fields of the cerebral cortex were analyzed. Scale bar = 5μm. The figures show quantification of (C) Caspase (D) TUNEL-positive cells. The results are given as the mean ± SD (n = 4). ** P < 0.01, * P < 0.05, compared with control group, and #P < 0.05, significantly different from Aβ-infused rats.

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