Figure_5.tif (1.48 MB)

Arrhythmia susceptibility after chronic β-adrenergic stimulation-induced cardiac hypertrophy.

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posted on 2013-08-30, 02:18 authored by Christina Westphal, Bastian Spallek, Anne Konkel, Lajos Marko, Fatimunnisa Qadri, Laura M. DeGraff, Carola Schubert, J. Alyce Bradbury, Vera Regitz-Zagrosek, John R. Falck, Darryl C. Zeldin, Dominik N. Müller, Wolf-Hagen Schunck, Robert Fischer

(A) Representative original tracings showing the induction of atrial fibrillation by programmed electrical stimulation in WT mice 2 weeks after chronic ISO infusion (upper panel) and the resistance of CYP2J2-TG mice treated in the same manner (lower panel). (B) Atrial fibrillation inducibility significantly increased in WT mice after chronic ISO infusion (n = 9) compared with the vehicle control (n = 8) and was significantly higher than in CYP2J2-TG mice (n = 7 and n = 8 for the vehicle and ISO groups). (C) The relative percentage of inducible sustained atrial fibrillation was markedly higher in WT compared with CYP2J2-TG after chronic ISO infusion. For statistical evaluation of arrhythmia inducibilities and severity scoring compare Fig. 2. Results represent mean±SEM; ANOVA, Post-Hoc Tukey; *p<0.05 vs. WT+Vehicle; †p<0.05 vs. CYP+Vehicle; ^‡p<0.05 vs. WT+ISO.