Apical CFTR expression in non-CF cells compared to CF cells.

<p>Ezrin and E-cadherin positive cells were analyzed for apical CFTR expression per individual by all observers and the mean percentage of cells displaying apical CFTR was plotted. <b>A.</b> Differences in distribution for the proportion of columnar epithelial cells expressing apical CFTR in non-CF individuals (n = 17) compared to individuals with CF homozygous for F508del-CFTR using Student’s t-test. Apical CFTR expression levels for CF patients with other mutations are displayed at the right scatter plot. A subject that expresses a CFTR allele associated with reduced gating is indicated in green (F508del/S1251N). Repetitive measurements of a single subject are indicated in red.</p>