Fig_6.tif (6.51 MB)
Ampicillin reduces aortic atherosclerosis without affecting MDA levels.
figure
posted on 2016-01-28, 12:39 authored by Ida Rune, Bidda Rolin, Christian Larsen, Dennis Sandris Nielsen, Jenny E. Kanter, Karin E. Bornfeldt, Jens Lykkesfeldt, Karsten Buschard, Rikke Kaae Kirk, Berit Christoffersen, Johannes Josef Fels, Knud Josefsen, Pernille Kihl, Axel Kornerup HansenA Plaque burden assessed with the “en face”-method showed significantly lower plaque burden in the thoracic aorta in ampicillin-treated animals compared to untreated animals (p = 0.0285). B MDA levels measured at 16 weeks of age did not show any differences between the groups. C Histological assessment of the oil red O-positive area at the aortic sinus did not show any differences between the groups. D Histological slide of three representative aortic sinus lesions, demonstrating complex lesions with cholesterol clefts and necrotic cores (40X, Stained with Oil Red O). (Graphs depicted with mean ± SEM).
