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Acquisition and reversal in the procedural T-maze.

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posted on 2015-08-14, 03:53 authored by Daniela Brunner, Patricia Kabitzke, Dansha He, Kimberly Cox, Lucinda Thiede, Taleen Hanania, Emily Sabath, Vadim Alexandrov, Michael Saxe, Elior Peles, Alea Mills, Will Spooren, Anirvan Ghosh, Pamela Feliciano, Marta Benedetti, Alice Luo Clayton, Barbara Biemans

In the procedural T-maze mice are trained to reach a platform on one side of the maze. After they perform correctly 6 out of 8 trials in two consecutive days, the platform position is reversed and mice are trained under the new rule. A: The proportion of mice that reached criteria during the acquisition (maximum 8 days) shows that there were no deficits in the 16p11.2 df/+ mice but Cntnap2 -/- mice learned the task faster; B: during reversal (6 days maximum) there were no deficits either. Note the reversal data for Cntnap2 WT mice are identical to that of the Cntnap2 -/- mice. Data shown are proportions of mice that started the task (Genotype Factor, Survival Analysis, Chi Square: **p < .01).

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