Ablation of XBP1 does not significantly affect the MCDS phenotype in <i>C/X</i> mice.

<p><i>(A-C)</i> Tibial epiphyseal cryosections from 2 week <i>Wt</i>, <i>Xbp1</i><sup><i>CartΔEx2</i></sup>, <i>ColX</i><sup><i>N617K</i></sup> and <i>C/X</i> mice stained with <i>(A)</i> haematoxylin and eosin (H&E), or by immunofluorescence using <i>(B)</i> anti-collagen II or <i>(C)</i> anti-collagen X antibodies; B—Bone; HZ—Hypertrophic Zone; PZ—Proliferative Zone; SCO—Secondary Center of Ossification. <i>(D-F)</i> Quantification of growth plate <i>(D)</i> resting zone, <i>(E)</i> proliferative zone, and <i>(F)</i> hypertrophic zone lengths in mutant and <i>Wt</i> mice; N = 3 for each genotype; statistical analysis performed using Student’s <i>t</i> test.</p>