Figure_5.tif (3.49 MB)
Aberrant Neural Differentiation of FXS iPSC-derived Neuronal Progenitors.
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posted on 2011-10-12, 01:48 authored by Steven D. Sheridan, Kraig M. Theriault, Surya A. Reis, Fen Zhou, Jon M. Madison, Laurence Daheron, Jeanne F. Loring, Stephen J. HaggartyImmunocytochemical analysis of Tuj1 expression (green) in neuronal progenitor cells differentiated upon mitogen removal of (A) FMRP+ control line 8330-8 and (B) FMRP- FXS line 848-3, overlaid with nuclei DNA staining (blue) (see Figure S1 for additional images). (C) Quantification of neurite process length in indicated iPSC-NP lines. Two wells (6-well plate) were imaged, 9 images per well (n = 18 images per sample). P-values as indicated *1.5e-13, **1.1e-10, ***3.1e-13, ****1.4e-4.
