Fig_7.tif (519.09 kB)
A proposed scheme of pathogenesis of HS.
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posted on 2015-06-19, 03:31 authored by Theodora Kanni, Vassiliki Tzanetakou, Athina Savva, Brigit Kersten, Aikaterini Pistiki, Frank L. van de Veerdonk, Mihai G. Netea, Jos W. van der Meer, Evangelos J. Giamarellos-BourboulisPatients with HS have monocytosis but cytokine responses of inflammatory monocytes and T17 lymphocytes are inhibited. This inhibition is mediated for T17 cells by tumour necrosis factor-alpha (TNFα). When cells migrate to tissues from the blood vessels through the vascular endothelium, capacity for excess production of TNFα, interleukin (IL)-1β, IL-1α, IL-6 and IL-17 is restored.
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cytokine gene copiescytokine profilesHurley III patientshsweek 8. ConclusionsFindingsHidradenitis Suppurativa BackgroundFavorable treatment outcomes120 patientspbmchidradenitis suppurativaTNF blockadeCompartmentalized Cytokine Responsescytokine responsesmonocyteflow cytometrycytokine productionClinical improvementilmeasured.ResultsCD 14brightCDcompartmentalized cytokine expressionIsolated blood
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