A neutralizing antibody to IL-12 p40 protects β-cells from PIC-induced apoptosis.

(A) MCP-1 gene expression in PIC-treated βTC-3 cells without or with IL-12 p40 neutralizing antibody. (B) Caspase-3 activity in PIC-treated βTC-3 cells without or with IL-12 p40 neutralizing antibody. Graph (B) shows pro-caspase-3 cleavage (RFU). # p < 0.05, ## p < 0.01 relative to PIC and n = 3.