A measure of Aβ pore toxicity in terms of effect on the gating of other channels in the neighborhood.

<p>The open probability of IP<sub>3</sub>R at [IP<sub>3</sub>] = 100nM (A), normalized current through Ca<sup>2+</sup>-activated Cl<sup>-</sup> channel at membrane potential, V = -40mV (B), and open probability of BK channel at V = -60mV (C) and 40mV (D) respectively as a function of distance from the center of an active Aβ pore of type 1 (black), 2 (blue), 3 (red), 4 (purple), and 5 (green).</p>