<div><p><b>The effect of Mdivi-1 on migration of mt-SOD1<sup>G93A</sup>-Dendra expressed in normal muscle fibers</b>.</p> <p>(<b>A</b>) Migration in the presence of Mdivi-1; (<b>B</b>). Migration in DMSO as a control. (<b>C</b>) The migration time course of mt-SOD1<sup>G93A</sup>-Dendra. Solid lines are the linear regression of the data after 2 minutes of the photoactivation. Dashed lines are the linear regression of the data in the first 2 minutes. The migration rates are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082112#pone-0082112-t001" target="_blank">Table <b>1</b></a>. (P<0.01). Note, Mdivi-1 closely restored the migration rate of mutant mt-SOD1<sup>G93A</sup>-Dendra. (<b>D</b>) Western blot analysis of Mfn1, Mfn2 and Drp1 in skeletal muscle of G93A and control (ctrl) mice. There are no significant changes in expression level of these mitochondrial fusion/fission proteins in G93A muscle at the age of 2 month. (n=5 mice for control and G93A respectively).</p></div>