Figure_5.tif (779.96 kB)
ATP degradation, P2X7 inhibition and Caspase-1 and inflammasome inhibition attenuated the protective effect of ATP against bacterial infection.
figure
posted on 2013-05-22, 07:54 authored by Yang Xiang, Xuan Wang, Chao Yan, Qian Gao, Sheng-An Li, Jie Liu, Kaifeng Zhou, Xiaolong Guo, Wenhui Lee, Yun Zhang(A) YVAD (5 mg/kg), Apyrase (50 U/kg) or BBG (60 mg/kg) pre-injection prior to ATP reduced the survival rate of the mice infected with E. coli 25922 (n = 10, P<0.05 by log-rank test). (B) YVAD (5 mg/kg), Apyrase (50 U/kg) or BBG (60 mg/kg) pre-injection before ATP reduced the survival rate of mice infected with S. aureus 25923 (n = 10, P<0.05 by log-rank test).
