APOE is a contributor to exercise-induced preservation of neurovascular integrity.

<p>(A and B) Voluntary running does not change vascular and extravascular deposition of FIBRIN (red) in aged <i>Apoe</i><sup><i>-/-</i></sup> mice. Endothelial cells (cyan) are immunolabeled with CD31. (C and D) PDGFRβ<sup>+</sup> pericyte number (magenta) but not coverage, is only partially increased in aged Rn <i>Apoe</i><sup><i>-/-</i></sup> mice compared to controls. (E and F) The number of IBA1<sup>+</sup> microglia/monocytes (green) is not reduced by running in aged <i>Apoe</i><sup><i>-/-</i></sup> mice. Values in (B, D, and F) are mean <u>+</u> SEM, (B) <i>n =</i> 6 and (E–G) <i>n =</i> 3–4 per group. In (D) <i>**p</i> = 0.0024, <i>*p</i> = 0.0468, <i>*p</i> = 0.0166, and <i>*p</i> = 0.0430, and in (F) **<i>p</i> = 0.0022 and 0.0084, and *<i>p</i> = 0.0105 by ANOVA followed by Tukey’s posthoc tests. Scale Bars: 50 μm. The data used to make this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002279#pbio.1002279.s001" target="_blank">S1 Dataset</a>.</p>