APOE is a contributor to exercise-induced preservation of neurovascular integrity.

(A and B) Voluntary running does not change vascular and extravascular deposition of FIBRIN (red) in aged Apoe^-/- mice. Endothelial cells (cyan) are immunolabeled with CD31. (C and D) PDGFRβ⁺ pericyte number (magenta) but not coverage, is only partially increased in aged Rn Apoe^-/- mice compared to controls. (E and F) The number of IBA1⁺ microglia/monocytes (green) is not reduced by running in aged Apoe^-/- mice. Values in (B, D, and F) are mean + SEM, (B) n = 6 and (E–G) n = 3–4 per group. In (D) **p = 0.0024, *p = 0.0468, *p = 0.0166, and *p = 0.0430, and in (F) **p = 0.0022 and 0.0084, and *p = 0.0105 by ANOVA followed by Tukey’s posthoc tests. Scale Bars: 50 μm. The data used to make this figure can be found in S1 Dataset.