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Yb3+/Ho3+ Co-Doped Apatite Upconversion Nanoparticles to Distinguish Implanted Material from Bone Tissue
journal contribution
posted on 2016-09-27, 00:00 authored by Xiyu Li, Haifeng ChenThe exploration of bone reconstruction
with time requires the combination
of a biological method and a chemical technique. Lanthanide Yb3+ and Ho3+ co-doped fluorapatite (FA:Yb3+/Ho3+) and hydroxyapatite (HA:Yb3+/Ho3+) particles with varying dopant concentrations were prepared by hydrothermal
synthesis and thermal activation. Controllable green and red upconversion
emissions were generated under 980 nm near-infrared excitation; the
FA:Yb3+/Ho3+ particles resulted in superior
green luminescence, while HA:Yb3+/Ho3+ dominated
in red emission. The difference in the green and red emission behavior
was dependent on the lattice structure and composition. Two possible
lattice models were proposed for Yb3+/Ho3+ co-doped
HA and FA along the hydroxyl channel and fluorine channel of the apatite
crystal structure. We first reported the use of the upconversion apatite
particles to clearly distinguish implanted material from bone tissue
on stained histological sections of harvested in vivo samples. The
superposition of the tissue image and material image is a creative
method to show the material-tissue distribution and interrelation.
The upconversion apatite particles and image superposition method
provide a novel strategy for long-term discriminable fluorescence
tracking of implanted material or scaffold during bone regeneration.
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Ybmaterial imagechemical techniquenovel strategyupconversion emissionstissue imageHohydroxyl channelbone tissuebone regenerationdopant concentrationsHAlattice modelsmaterial-tissue distributionhydrothermal synthesisbone reconstructionlattice structureDistinguish Implanted Materialvivo samplesFABone Tissuediscriminable fluorescencefluorine channelupconversion apatite particles980 nm near-infrared excitationimage superposition methodemission behaviorapatite crystal structurehistological sections
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