Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

Dehbi, Oussama; Ishak, Esam A.; Bakht, Mohammed A.; Geesi, Mohammed H.; Alshammari, Mohammed B.; Chagnault, Vincent; Kaiba, Abdellah; Lazar, Saïd; Riadi, Yassine

doi:10.6084/m9.figshare.5896987.v1

tgcl_a_1437225_sm4328.docx (15.93 kB)

Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

journal contribution

posted on 2018-02-16, 12:34 authored by Oussama Dehbi, Esam A. Ishak, Mohammed A. Bakht, Mohammed H. Geesi, Mohammed B. Alshammari, Vincent Chagnault, Abdellah Kaiba, Saïd Lazar, Yassine Riadi

An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure.