Fig 4.tif (137.5 kB)
Volcano plot of array peptide phosphorylation after 15 minutes.
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posted on 2018-01-19, 21:09 authored by Unni Gopinathan, Kathrine Røe Redalen, Anne-Marie Trøseid, Peter Kierulf, Petter Brandtzaeg, Anne Hansen Ree, Jens Petter Berg, Reidun ØvstebøLog2 ratios between treatments (Nm, Nm+IL-10, IL-10) and unstimulated controls. Each dot represents a kinase peptide substrate. Red indicates significantly altered levels of phosphorylation (ANOVA, Dunnet, P<0.05). Dots to the left of the midline of the x-axis represent substrates with decreased phosphorylation, to the right substrates with increased phosphorylation.
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cell functionsVEGFmonocyte model systemstudy changessignal transduction10 6 NPTENLarge-scale reductiontyrosine kinase activitiesgene expression changesIngenuity Pathway Analysiskinase activitycell lysatesNf -κBmeningococcal sepsistyrosine kinase-mediated signal transductionmRNA levelsIL -10 anti-inflammatory responsevivo array peptide phosphorylationmRNA datatumor necrosis factorarray peptide phosphorylationanti-inflammatory cytokine interleukin -10meningitidis Ncytokine release144 kinase peptide substratesCXCL 10.15 minutesTNFZBTB60 minutesSTAT 3 activitykinase activitieskinase substrate arrays
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