Vectored immunoprophylaxis mediates a protective effect against limiting dose SIVsmE660 swarm challenge in rhesus macaques.
(A) Limiting dose intrarectal challenges were administered weekly as denoted in the Kaplan-Meier curve on the x-axis to animals receiving mAb (ITS01+ITS06.02) via AAV in our initial (blue, n = 6) and repeat (green, n = 4) groups or no mAb controls (gray, n = 24). Two animals were censored from analysis after challenge 2 due to false positive viral loads (vertical ticks) (B) Serum anti-SIV env transgene mAb was quantified and plotted (y-axis) versus time (x-axis) for mAb pretreated animals and four contemporaneous control animals. Diamonds indicate timepoint of infection corresponding to animals’ expression level line. Challenges at AID0.33 are denoted as grey downward facing triangles above. (C) Plasma viral loads (y-axis) are plotted versus time post infection (x-axis).