Pooja_SMBE_presentation_150712.pdf (4.68 MB)

Variable X/A divergence and male-mutation bias near and far from genes in Great Apes

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posted on 06.08.2015 by Pooja Narang, Melissa Wilson Sayres

The slides are from a presentation at the annual meeting of Society of Molecular Biology and Evolution at Vienna, Austria from July 12-16, 2015. 


While the role of natural selection is shaping the patterns of diversity is widely known, its impact in shaping the patterns of divergence along the long evolutionary timescales, are not well studied. We show that patterns of divergence near and far from genes on the X and autosomes are consistent with natural selection reducing inter-species genetic divergence in neutral regions near genes. Furthermore, the effect of natural selection on linked neutral sites appears to be stronger on the X chromosome, potentially confounding assessments that compare neutral divergence rates between the X and autosomes.