lsyc_a_1339803_sm3109.pdf (4.54 MB)
Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction
Version 2 2017-07-19, 15:08
Version 1 2017-06-14, 15:56
journal contribution
posted on 2017-07-19, 15:08 authored by Lili Zhang, Zhengkai Chen, Hongli Li, Wenguang Yin, Jianfeng Xu, Maozhong Miao, Hongjun RenA transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which was in situ generated from 2-bromopyridine with i-PrMgCl·LiCl.
