Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction

<p>A transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which was <i>in situ</i> generated from 2-bromopyridine with <i>i</i>-PrMgCl·LiCl.</p>