jo6b01899_si_001.pdf (6.62 MB)
Traceless OH-Directed Wacker Oxidation-Elimination, an Alternative to Wittig Olefination/Aldol Condensation: One-Pot Synthesis of α,β‑Unsaturated and Nonconjugated Ketones from Homoallyl Alcohols
journal contribution
posted on 2016-08-26, 00:00 authored by Venkati Bethi, Rodney A. FernandesA new method for
one-pot synthesis of β-substituted and β,β-disubstituted α,β-unsaturated methyl ketones
from homoallyl alcohols by sequential
PdCl2/CrO3-promoted Wacker process followed
by an acid-mediated dehydration reaction has been developed. Remarkably,
internal homoallyl alcohols delivered regioselectively nonconjugated
unsaturated carbonyl compounds under the same protocol. A new starting
material-based synthesis of α,β-unsaturated and nonconjugated methyl ketones is demonstrated.
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Olefinationcompoundacid-mediated dehydration reactionsequentialhomoallyl alcoholsWittigHomoallylβ-methodSynthesiCondensationKetonePdClTraceless OH-Directed Wacker Oxidation-Eliminationone-potNonconjugatednonconjugated methyl ketonesRemarkablycarbonyldisubstitutedCrOmaterial-basedOne-PotAlternativesynthesisUnsaturatedregioselectively
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