Total Synthesis of Hyacinthacine A<sub>1</sub> and 3-<i>epi</i>-Hyacinthacine A<sub>1</sub>
2005-06-23T00:00:00Z (GMT) by
Total synthesis of hyacinthacine A<sub>1</sub> and its epimer at C3 is described. The synthesis includes a stereocontrolled carboazidation of a chiral allylsilane as a key step. C−Si bond oxidation and reduction of the azide, with ring-closure, complete the total synthesis, which establishes the absolute configuration of <b>3</b>.