Total Synthesis of Hyacinthacine A1 and 3-epi-Hyacinthacine A1
2005-06-23T00:00:00Z (GMT) by
Total synthesis of hyacinthacine A1 and its epimer at C3 is described. The synthesis includes a stereocontrolled carboazidation of a chiral allylsilane as a key step. C−Si bond oxidation and reduction of the azide, with ring-closure, complete the total synthesis, which establishes the absolute configuration of 3.