ganp_a_1367768_sm2753.docx (2.25 MB)
Three new kavalactone dimers from Piper methysticum (kava)
journal contribution
posted on 2017-09-04, 11:08 authored by Yao Yuan, Jian-Xiang Yang, Ling-Hui Nie, Bai-Lin Li, Xu-Bing Qin, Jie-Wei Wu, Sheng-Xiang QiuThree new dimeric kavalactones, designated as diyangonins A–C (1–3), along with two known analogs were isolated from the roots of Piper methysticum. Their structures were elucidated by means of extensive analysis of their 1D, 2D NMR, and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units in head-to-tail or head-to-head mode. Compounds 1–5 were evaluated for their cytotoxic activities against human tumor cell lines.