Three new flavonoid glycosides from <i>Smilax glabra</i> and their anti-inflammatory activity

<p>Three new flavonoid glycosides, 2(<i>S</i>)-5-hydroxy-6,8-dimethoxyflavonone-7-O-<i>β</i>-D-glucopyranosyl-(1→6)-O-<i>β</i>-D-glucopyranoside (<b>1</b>), 5-hydroxy-3,8-dimethoxyflavone-7-O-<i>β</i>-D-glucopyranosyl-(1→6)-O-<i>β</i>-D-glucopyranoside (<b>2</b>) and 3,7-dihydroxy-8-methoxyflavone-6-O-<i>β</i>-D-glucopyranosyl-(1→6)-O-<i>β</i>-D-glucopyranoside (<b>3</b>), together with five known flavonoids (<b>4</b>–<b>8</b>) were isolated from the roots of <i>Smilax glabra</i> Roxb. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Three new flavonoids were subjected to evaluate anti-inflammatory activity. Compounds <b>1–3</b> inhibited the NF <i>κ</i>B induction by 32.2, 55.8 and 61.7%, respectively.</p>