The polysaccharide extracts from the fungi <i>Coprinus comatus</i> and <i>Coprinellus truncorum</i> do exhibit AChE inhibitory activity

<p>The polysaccharide (PSH) extracts from the edible mushroom species <i>Coprinus comatus</i> and <i>Coprinellus truncorum</i> were screened <i>in liquid</i> for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC<sub>50</sub> values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.</p>