tacs_a_1512520_sm1926.pdf (137.84 kB)
The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts
journal contribution
posted on 2018-08-25, 11:55 authored by Jie Li, Gaofu Wang, Jing Jiang, Lin Fu, Peng Zhou, Hangxing RenMicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.