jf205362d_si_001.pdf (2.33 MB)
The Limonoids and Their Antitobacco Mosaic Virus (TMV) Activities from Munronia unifoliolata Oliv.
journal contribution
posted on 2012-05-02, 00:00 authored by Yong-hui Ge, Kai-xing Liu, Jian-xin Zhang, Shu-zhen Mu, Xiao-jiang HaoFive new limonoids, named munronoids K–O (1–5), together with three known limonoids
were isolated from Munronia unifoliola Oliv. These
limonoids were involved in the skeletons of evodulone, gedunin, and
peieurianin types of limonoids, and their structures were established
on the basis of spectroscopic data. Compound 5 featuring
a γ-lactone ring instead of the β-substituted furan ring
was found in the peieurianin type for the first time. The antitobacco
mosaic virus (anti-TMV) activities of compounds 1–8 were also evaluated with half-leaf, enzyme-linked immunosorbent
assay, and Western blot methods, and limonoids 1, 5, and 8 showed stronger anti-TMV treatment activities
than the positive control ningnanmycin. Six compounds (1–5 and 8) exhibited infection inhibition
activities against TMV.