sorry, we can't preview this file
lsyc_a_1459720_sm9193.docx (5 MB)
Synthesis of pyrazolopyrimidinones as sildenafil derivatives and sclerotigenin
journal contribution
posted on 2018-06-08, 18:37 authored by Hoon Gu Heo, Jin Yu, Raveendra Jillella, Chang Ho OhA series of novel pyrazolo pyrimidinone derivatives (3(a–d), 4(a–d), and 6(a–d)) was synthesized from various pyrazolo amides (2a–d) which are synthesized by the reaction between ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) and various lithium amides. In addition, we also described the synthesis of sclerotigenin drug molecule which has quinazoline moiety from simple 2-nitro benzoic acid with high yields.