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Synthesis of Si containing Dopamine
Version 2 2014-12-16, 12:48
Version 1 2013-03-14, 21:11
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posted on 2014-12-16, 12:48 authored by OS BH-LabsOS BH-LabsDopamine cannot cross the blood-brain barrier as is, but with Si incorporated that may no longer be the case. In addition, the Si strategically placed would prevent conversion to Dopal (which is the undersired metabolite of Dopamine) following deamination with MAO. Some recent litereature suggests that Si containing compounds more easily cross the blood-brain barrier.
If you'd like more information on this project/idea, you may contact me at:
Jamie@itsmoleculardesign.com
Some preliminary references:
- Chemistry & Biology 8 (2001) 1161-1166
- Journal of Alzheimer's disease 11 (2007) 295-304
Thoughts & Comments are welcome at the email address listed above.
