ol6b03090_si_001.pdf (2.75 MB)
Synthesis of Secondary and Tertiary Alkylboranes via Formal Hydroboration of Terminal and 1,1-Disubstituted Alkenes
journal contribution
posted on 2016-10-27, 12:33 authored by Hilary
A. Kerchner, John MontgomeryCopper-catalyzed
functionalization of terminal or 1,1-disubstituted
alkenes with bis(pinacolato)diboron and methanol provides formal hydroboration
products with exceptional regiocontrol favoring the branched isomer.
Pairing this procedure with photocatalytic cross-couplings using iridium
and nickel cocatalysis provides an effective, highly regioselective
procedure for the hydroarylation of terminal alkenes.