Synthesis of Pyrido[1,2-<i>a</i>]indole Malonates and Amines through Aryne Annulation
2012-03-16T00:00:00Z (GMT) by
Pyrido[1,2-<i>a</i>]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-<i>a</i>]indoles in moderate to good yields.