Synthesis of Oxadiazolo-, Pyrimido-, Imidazolo-, and Benzimidazolo-Containing Derivatives of 1,4-Benzodiazepin-5-(4′-methylpiperazinyl)-carboxamide Through Phenylamino Spacer

Versatility of amidine and imidate derivatives of 5-carboxamido-1,4-benzodiazepin-5-(4′-methylpiperazinyl)-carboxamide (8 and 9) was explored to provide easy access to its 2-(oxadiazolo, pyrimido, imidazolo, and benzimidazolo)-substituted analogs 10, 11, 13, and 14, respectively, through the phenylamino spacer.