Synthesis of Oxadiazolo-, Pyrimido-, Imidazolo-, and Benzimidazolo-Containing Derivatives of 1,4-Benzodiazepin-5-(4′-methylpiperazinyl)-carboxamide Through Phenylamino Spacer

2014-10-02T00:00:00Z (GMT) by Navjeet Kaur Dharma Kishore
<div><p></p><p>Versatility of amidine and imidate derivatives of 5-carboxamido-1,4-benzodiazepin-5-(4′-methylpiperazinyl)-carboxamide (<b>8</b> and <b>9</b>) was explored to provide easy access to its 2-(oxadiazolo, pyrimido, imidazolo, and benzimidazolo)-substituted analogs <b>10</b>, <b>11</b>, <b>13</b>, and <b>14</b>, respectively, through the phenylamino spacer.</p> </div>