ol502900j_si_001.pdf (13.11 MB)
Synthesis of Highly Substituted Imidazolidine-2,4-dione (Hydantoin) through Tf2O‑Mediated Dual Activation of Boc-Protected Dipeptidyl Compounds
journal contribution
posted on 2014-11-21, 00:00 authored by Hui Liu, Zhimin Yang, Zhengying PanHighly substituted
chiral hydantoins were readily synthesized from
simple dipeptides in a single step under mild conditions. This reaction
proceeded through the dual activation of an amide and a tert-butyloxycarbonyl (Boc) protecting group by Tf2O-pyridine.
This method was successfully applied in the preparation of a variety
of biologically active compounds, including drug analogs and natural
products.